• Fr. Robert G. Kreckel, March 1973-1985
• Fr. Lawrence V. Murphy, 1985-June 29, 1993
• Fr. Louis A. Vasile, June 29, 1993-Sep. 1, 1998
• Fr. William J. Graf, Sep. 1, 1998-June 25, 1999 [Administrator], June 25, 1999-June 28, 2005 [Pastor]
• Nancy DeRycke, June 28, 2005-June 2008
• Sr. Joan Cawley, June 2008-June 2014
• Fr. Edward Palumbos, June 2014-June 26, 2018 [upon retirement]
• Fr. George P. Heyman, June 26, 2018-April 21, 2021 [upon death]
• Fr. Peter C. Clifford, April 16, 2021-June 29, 2021 [Temporary administrator]
• Fr. William F. McGrath Jr., June 29, 2021-present

Church of the Resurrection was established by Bp. Hogan to serve eastern Perinton in March of 1973 because of extensive growth at Church of the Assumption. Fr. Robert Kreckel was transferred from Immaculate Conception in the Corn Hill area to serve as the parish's founding Pastor. Various meetings were held with 205 individuals who would comprise the charter members of the new parish. Soon, Masses were offered in a building adjacent to Martha Brown Junior High School on Sundays and in the Hamilton Road rectory basement on weekdays. The church building was completed and Masses transferred to there on October 9, 1976. The parish has always been fairly small in size, but by the late 1990s the number of families had risen to 579.

Early in 2014, it was announced that Resurrection would share pastoral leadership with neighboring Church of the Assumption in Fairport. Fr. Edward Palumbos was appointed Pastor of both parishes with Fr. George Heyman, previously the assisting priest under Sr. Joan Cawley, continuing to assist at Resurrection. Sr. Joan Cawley has shifted into the role of Pastoral Associate.